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Padcev 20 mg Injection contains enfortumab vedotin, an antibody-drug conjugate used in the treatment of certain advanced cancers, specifically urothelial carcinoma (a type of bladder cancer). It targets Nectin-4, a protein highly expressed on urothelial cancer cells, delivering a cytotoxic agent directly to the cancer, reducing tumor growth.

Uses:

1. Treatment of Advanced or Metastatic Urothelial Carcinoma: Typically prescribed for patients who have previously received immunotherapy and platinum-containing chemotherapy.
2. Indicated for Certain Bladder Cancers: Used when disease has progressed or if other therapies have failed.

How Padcev Works: Enfortumab vedotin binds to Nectin-4 on cancer cells, delivering a potent chemotherapy agent that induces cell death. By targeting cancer cells directly, it minimizes exposure to normal tissues, enhancing effectiveness.

Common Side Effects:

• Fatigue
• Skin rash or itching
• Nausea and decreased appetite
• Peripheral neuropathy (numbness or tingling in extremities)
• Elevated blood sugar levels (hyperglycemia)

Serious Side Effects (Seek Immediate Medical Attention):

• Severe skin reactions (e.g., Stevens-Johnson Syndrome)
• High blood sugar (diabetic ketoacidosis)
• Infusion site reactions
• Respiratory complications

Key Features:

• Contains enfortumab vedotin, an antibody-drug conjugate targeting Nectin-4.
• Indicated for advanced urothelial carcinoma where prior therapies have not worked.
• Administered as an intravenous infusion by a healthcare professional.
• Combines targeted therapy with a potent cytotoxic agent for enhanced treatment specificity.

Precautions:

• Pregnancy Safety: Not recommended for use during pregnancy due to potential harm to the fetus. Effective contraception is advised for both men and women during and after treatment.
• Monitoring: Regular monitoring of blood sugar levels and skin conditions is essential during treatment.

1. What is Padcev 20 mg Injection used for?
   Padcev is used to treat advanced or metastatic urothelial carcinoma (bladder cancer), particularly in patients who have not responded to other therapies.
2. How is Padcev administered?
   It is given as an intravenous infusion by a healthcare provider, typically on a scheduled basis.
3. What precautions should be taken during Padcev treatment?
   Close monitoring of skin reactions, blood sugar, and infusion reactions is necessary. Patients with a history of diabetes should manage blood sugar levels closely.

• Salient features of Dispovan 5ml syringe With 24G Needle :
• Barrels are made of nontoxic, medical-grade polypropylene compatible with any medication.
• The tip of the barrel is of two types – luer mount and luer lock. Both have a 6% luer taper as per ISO:594.
• Plungers are made of nontoxic, medical-grade polypropylene compatible with any medication.
• Gaskets are made of natural rubber which is chemically inert and compatible with medication for short term contact drug delivery application.

CRESEMBA 100MG CAPSULES belongs to the class of medicines called antifungals used to treat fungal infections such as invasive aspergillosis and mucormycosis. Invasive aspergillosis is an infection caused by Aspergillus fungus. It occurs when the infection spreads from lungs to kidneys, brain, heart or skin. Mucormycosis is a rare but serious fungal infection of the skin or respiratory system that occurs in people with weakened immune systems.

CRESEMBA 100MG CAPSULES contains Isavuconazole (antifungal) that works by inhibiting the synthesis of fungal cell membranes, which are essential for their survival. Thereby, CRESEMBA 100MG CAPSULES kills or inhibits the growth of the fungus.

Take CRESEMBA 100MG CAPSULES as prescribed by your doctor. You are advised to take CRESEMBA 100MG CAPSULES for as long as your doctor has prescribed it for you based on your medical condition. Some people may experience headache, decreased appetite, drowsiness, nausea, vomiting, stomach pain, diarrhoea or chest pain. Most of these side effects of CRESEMBA 100MG CAPSULES do not require medical attention and gradually resolve over time. However, if the side effects worsen or persist, please consult your doctor.

If you are allergic to CRESEMBA 100MG CAPSULES or any other medicines, please tell your doctor. CRESEMBA 100MG CAPSULES is not recommended for children below 18 years as the safety and effectiveness were not established. If you are pregnant, it is advised to consult a doctor before using CRESEMBA 100MG CAPSULES. Avoid breastfeeding while taking CRESEMBA 100MG CAPSULES. Drive only if you are alert after taking CRESEMBA 100MG CAPSULES as it may cause drowsiness, confusion or tiredness. Avoid alcohol consumption while taking CRESEMBA 100MG CAPSULES as it may increase the risk of liver damage.

1. Tenvir-EM (Tenofovir Disoproxil Fumarate and Emtricitabine):

   • Uses: Tenvir-EM is a combination medication used as part of HIV treatment regimens, often in combination with other antiretroviral drugs.
   • Precautions:
     • Regular monitoring of kidney function is important as tenofovir can affect the kidneys.
     • It may be used with caution in patients with bone-related issues.
     • Inform your healthcare provider about all other medications you are taking to check for potential interactions.
   • Side Effects:
     • Common side effects may include nausea, diarrhea, headache, and fatigue.
     • More serious side effects can include kidney problems and changes in bone density.

2. Efavir (Efavirenz):

   • Uses: Efavir is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with other antiretroviral medications for the treatment of HIV.
   • Precautions:
     • It may cause dizziness or drowsiness, so caution is advised when operating machinery or driving.
     • Efavir is typically taken at bedtime to help manage side effects.
     • Inform your healthcare provider about any psychiatric or mood disorders.
   • Side Effects:
     • Common side effects include dizziness, vivid dreams, and rash.
     • Serious side effects may include liver problems and psychiatric symptoms.

3. Duovir (Zidovudine and Lamivudine):

   • Uses: Duovir is a combination of zidovudine and lamivudine, both nucleoside reverse transcriptase inhibitors (NRTIs), used in the treatment of HIV.
   • Precautions:
     • Regular blood tests may be needed to monitor for side effects, especially related to blood cell counts.
     • Inform your healthcare provider about any history of anemia or liver problems.
   • Side Effects:
     • Common side effects may include nausea, headache, and fatigue.
     • Zidovudine may cause anemia, and lamivudine may cause changes in liver function.